Factor XIII, also known by the name fibrin stabilizing factor, is a key clotting factor in the coagulation cascade known for stabilizing the formation of a blood clot. The plasma form of Factor XIII is a protein heterodimer of A and B subunits expressed by bone marrow and mesenchymal lineage cells remarkable for its function as a The biologic process of bone healing is complicated, involving a variety of cells, cytokines, and growth factors. As a result of bone damage, the activation of a clotting cascade leads to hematoma with a high osteogenic potential in the initial stages of healing. A major factor involved in this course of events is clotting factor XIII (FXIII
Identification of eight novel coagulation factor XIII subunit A ...
The inhibitory effect of coagulation factor XIII (FXIII) on fibrinolysis has been studied for at least 50 years. Our insight into the underlying mechanisms has improved considerably, aided in particular by the discovery that activated FXIII cross-links α2-antiplasmin (α2AP) to [HOST] this review, the most important effects of different cross The present knowledge about clotting F XIII is roughly displayed. It is explained why F XIII is not a clotting factor in the strict sense of the word and that its biological function more general is the crosslinking of proteins via a transamidase reaction, the reduction of the permeability of the microvasculature, the stimulation of connective tissue cells, and finally
(PDF) Coagulation Factors: An Overview - ResearchGate
The plasma circulating zymogenic coagulation factor XIII (FXIII) is a protransglutaminase, which upon activation by thrombin and calcium cross-links preformed fibrin clots/fibrinolytic inhibitors making them mechanically stable and less susceptible to fibrinolysis. The zymogenic plasma FXIII molecule is a heterotetramer composed of two IV. THE ACTION OF ACTIVATED FACTOR XIII V. FACTOR XIII IN WOUND HEALING AND VI. OTHER EFFECTS OF FACTOR XIII VII. FACTOR XIII AS AN INTRACELLULAR VIII. SUMMARY, CONCLUSIONS, AND I. INTRODUCTION The history of blood coagulation factor XIII (FXIII) started more than 70 years ago,