Methods: Venous blood was withdrawn from 12 volunteers in a crossover study. Four percent succinylated gelatin was added to citrated whole-blood samples to make a 40 vol% end-concentration of gelatin. The baseline and 40 vol% samples, and samples with addition of fresh-frozen plasma (FFP), fibrinogen, coagulation factors XIII (FXIII) or VIII Factor XIII or fibrin stabilizing factor is a zymogen found in blood of humans and some other animals. It is activated by thrombin to factor XIIIa. Factor XIIIa is an Keywords: Factor XIII-A, transglutaminase, cross-linking, cellular FXIII-A, haemostasis, wound healing. Go to: 1. Background. FXIII belongs to the Tretten ® (Coagulation Factor XIII A-Subunit [Recombinant]) Kohler HP, Ichinose A, Seitz R, Ariens RAS, Muszbek L; Factor XIII and Fibrinogen SSC Subcommittee of the ISTH. Diagnosis and classification of factor XIII deficiencies. J Thromb Haemost. ;9(7) The discovery of coagulation factor XIII (FXIII) dates back to s when a “serum factor” was found to make the fibrin clot insoluble in concentrated Coagulation factor XIII (FXIII) is activated in the last stage of the coagulation cascade in the presence of thrombin and Ca 2+ by cleavage and release of the activation peptide (FXIII activation peptide, AP-FXIII) from the A-subunit and dissociation of the carrier B-subunits. Activated FXIII then crosslinks fibrin fibers and incorporates Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration James R. Byrnes, James R. Byrnes 1 Department of Pathology and Laboratory Medicine and UNC Blood Research Center, The University of North Carolina at Chapel Hill
Evaluation of a Blood Coagulation Factor XIII Assay Kit - KoreaMed
Blood coagulation factor XIII: structure and function. Blood coagulation factor XIII: structure and function Thromb Res. Jun 1;94(5) doi: /s(99) Authors L Muszbek 1, V C Yee, Z Hevessy. Affiliation 1 Department of Clinical Abstract. Coagulation factor XIII (FXIII) acts as a fine fulcrum in blood plasma that maintains the balance between bleeding and thrombosis by covalently crosslinking the pre-formed fibrin clot into an insoluble one that is resistant to premature fibrinolysis. In plasma, FXIII circulates as a pro-transglutaminase complex composed of the dimeric 1. Introduction. Factor XIII (FXIII) is a protransglutaminase whose activated form (FXIIIa) is the final enzyme in the sequence of blood coagulation biochemistry and plays a key role in clot stabilization and maturation [1,2].In plasma, FXIII circulates as a non-covalent, zymogen heterotetramer (FXIII-A 2 B 2) comprising two catalytic A-subunits and Coagulation factor XIII (FXIII) is a zymogenic transglutaminase constituted by 2 potentially active A subunits (FXIII-A) and 2 carrier-inhibitory B Blood coagulation factor XIII and factor XIII deficiency. Nov;30 (6) doi: /[HOST] Factor XIII (FXIII) is a multifunctional pro-γ-transglutaminase that, in addition to its well-known role in hemostasis, has a crucial role in angiogenesis, maintenance of pregnancy, wound healing, bone metabolism, and even cardio Abstract. Factor XIII (FXIII) is unique among clotting factors for a number of reasons: 1) it is a protransglutaminase, which becomes activated in the last stage of
(PDF) Coagulation Factors: An Overview - ResearchGate
Background. Factor XIII is a kDa tetramer, comprising two enzymatic A-subunits and two carrier B-subunits (FXIII A 2 B 2).Activated FXIII (FXIIIa) catalyses the formation of ε-(γ-glutamyl)lysyl covalent bonds between γ-γ, γ-α and α-α chains of adjacent fibrin molecules and also cross-links the major plasmin inhibitor, α2-antiplasmin, to fibrin Evaluation of a Blood Coagulation Factor XIII Assay Kit Sookwon Ryu, M.D.1,2,3, Seong Soo An, Ph.D.4 and In Bum Suh, M.D.1,2,3 1Department of Laboratory Medicine, 2Institute of Medical Science, 3KCMIT Center, Kangwon National University College of Medicine, Chuncheon, 키트는 photometric assay를 이용하는 Dade사(behring- The factor XII (FXII)–driven contact system and its activator polyphosphate (polyP) can serve as a paradigm that connects coagulation and