Target Information. The GM-CSF gene encodes for a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space. This gene is located in a cluster of related genes at the chromosome region 5q31, which has been associated with It facilitates hematopoietic recovery after bone marrow transplantation. Human M-CSF is reactive in murine systems, but the murine molecule exhibits no activity on Recombinant Human GM-CSF (carrier-free) - GM-CSF plays a key role in signaling emergency hemopoiesis (predominantly myelopoiesis) in response to infection, including the production of granulocytes and macrophages in the bone marrow and their maintenance, survival, and functional activation at sites of injury or insult Characterization of human macrophages has been widely studied, but polarized macrophages in rabbits have not been characterized. We characterized rabbit macrophages that were polarized using human recombinant GM ‐ CSF and M‐ CSF. GM ‐ CSF ‐treated macrophages had higher mRNA expression of proinflammatory cytokines $ - $ Specifications. View More Specs. Products 2. Description. Specifications. Description. Human M-CSF Recombinant Protein for Western Human osteoclasts; consequently, M-CSF is a potent stimulator of mature osteoclast resorbing activity. Also, M-CSF induces VEGF in human monocytes in human
MACS® GMP Recombinant Human M-CSF - Miltenyi Biotec
In a sterile conical tube, prepare complete RPMI medium with M-CSF Recombinant Human Protein at a final concentration of ng/mL. Optional: Add 20 ng/mL IL-4 Recombinant Human Protein. Replace media in culture dish with the prepared media containing M-CSF and IL-4 (if using). Incubate cells for 6 days in 5% CO 2 incubator at The activity of recombinant human growth hormone (rhGH) in enhancing CD34(+) cell mobilization elicited by chemotherapy plus recombinant human granulocyte colony-stimulating factor (rhG-CSF) was evaluated in 16 hard-to-mobilize patients, that is, those achieving a peak of circulating CD34+ cells 10/microL or less, or a collection of Stability Testing for Recombinant Human M-CSF. Recombinant human M-CSF was aliquoted in PBS at mg/mL. One aliquot was frozen and thawed four times (4x Freeze/Thaw), and compared to a control kept at 4°C (Control). The samples were tested in a proliferation assay with M-NFS mouse myelogenous leukemia lymphoblast cells Gibco™ Human M-CSF Protein, PeproTech®, Catalog # UG. Tested in Western Blot (WB), ELISA (ELISA) and Functional Assay (FN) applications. Recombinant Human M-CSF is a kDa homodimeric protein consisting of two amino acid polypeptide subunits. This product is shipped at ambient temperature. For storage, handling and It is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. Recombinant human M-CSF is a kDa homodimeric and glycosylated. References. Kawasaki ES, et al (). Science (): Stein J, Borzillo GV, Rettenmier CW (). Blood 76 (7): The macrophage colony-stimulating factor (M-CSF) is a potent hematopoietic cytokine that is involved in diverse processes, such as regulation of inflammatory G-CSF (Granulocyte colony stimulating factor) is a naturally occurring cytokine that stimulates the production and antibacterial function of neutrophils and monocytes. Human G-CSF is an kDa protein containing amino acid residues, and a soluble isoform of the G-CSF receptor has been described. The pleotropic cytokine is produced by
Human M-CSF Antibody MAB216-100: R&D Systems
M-CSF recombinant proteins are available for Human, Mouse and Rat. These Protein have been validated for use in the following applications: Functional The self-renewing macrophages were readily obtained by long-term culture of mouse bone marrow cells with macrophage colony-stimulating factor (M