1 Introduction. Blood coagulation factor XIII (FXIII) is a heterotetrameric zymogen consisting of two catalytic A (FXIII-A) and two inhibitory/carrier B (FXIII-B) subunits. FXIII is converted into an active transglutaminase (FXIIIa) by the concerted action of thrombin and Ca 2+ in the final phase of the coagulation cascade Coagulation factor XIII (FXIII, or FXIII/13 to avoid confusion with FVIII/8 and FXII/12 Footnote 1) is a pro-enzyme of plasma transglutaminase (TGase) consisting of two enzymatic A subunits (FXIII-A) and two non-catalytic B subunits (FXIII-B), and plays a critical role in the generation of a stable hemostatic plug [1, 2].Thus, FXIII is also called a fibrin Abstract. Coagulation factor XIII (FXIII) is converted by thrombin into its active form, FXIIIa, which crosslinks fibrin fibers, rendering clots more stable and resistant to degradation. FXIII affects fibrin clot structure and function leading to a more prothrombotic phenotype with denser networks, characterizing patients at risk of venous Multidisciplinary research from the last few decades has revealed that Factor XIII subunit A (FXIII-A) is not only involved in blood coagulation, but may
Factor XIII subunits are stronger together | Blood | American …
The present knowledge about clotting F XIII is roughly displayed. It is explained why F XIII is not a clotting factor in the strict sense of the word and that its biological function more general is the crosslinking of proteins via a transamidase reaction, the reduction of the permeability of the microvasculature, the stimulation of connective tissue cells, and finally Objective: To relate factor XIII levels and other prothrombotic markers to inflammatory bowel disease and investigate the frequency of valine34leucine and its effect on factor XIII cross-linking activity in patients with inflammatory bowel disease. Design: Fifty patients with active inflammatory bowel disease but no venous thromboembolism (32 with ulcerative colitis, The factor XII (FXII)–driven contact system and its activator polyphosphate (polyP) can serve as a paradigm that connects coagulation and
Coagulation factor XIII is a critical driver of liver regeneration ...
The activation and regulation of coagulation Factor XIII (FXIII) protein has been the subject of active research for the past three decades. Although discrete evidence exists on various aspects of FXIII activation and regulation a combinatorial structure/functional view in this regard is lacking. In Factor XIII assay. Coagulation factor XIII is a transglutaminase that catalyzes covalent cross-linking bonds between the α and γ chains of fibrin polymer. Tags