M-CSF was first characterized as a glycoprotein that induces monocyte and macrophage colony formation from precursors in murine bone marrow cultures. M-CSF is Administration of recombinant CSF1 to humans or animals leads to monocytosis and expansion of tissue macrophage populations and growth of the liver Human M-CSF. 2 Reviews. Recombinant human M-CSF can regulate the proliferation, differentiation, and survival of monocytes, macrophages, osteoclasts and their Description. Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor is produced by our Mammalian expression system and the target gene encoding AlaGlu is expressed with a 6His tag at the C-terminus. Accession. P Known As. Granulocyte-macrophage colony-stimulating factor; Colony-stimulating factor; CSF. Mol Mass. KDa
Functions of macrophage colony-stimulating factor (CSF1
Macrophage Colony Stimulating Factor (M-CSF), also named CSF-1, is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. It is produced by osteoblasts (as a result of endocrine stimulation by parathyroid hormone) exerts paracrine effects on Background: M-CSF. M-CSF, also known as CSF-1, is a four-alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation (1 - 3). M-CSF is also essential for the survival and proliferation of osteoclast progenitors (1, 4). M-CSF also primes and enhances macrophage killing of tumor cells and Biolegend Recombinant Human M-CSF (carrier-free) Manufacturer: Biolegend Recombinant Human M-CSF (carrier-free) Apps: BA; Size: 25 ug. Catalog No. $ / Each of 1; Qty. Add to cart Description; SDS; Documents; Product Certifications Human M-CSF receptor cDNA encodes a amino acid (aa) type I membrane protein with a 19 aa signal peptide, a aa extracellular region containing the ligand-binding domain, a 25 aa transmembrane domain and a aa cytoplasmic domain. The human M-CSF R ECD shares 60%, 64%, 72%, 75%, 75% and 76% aa identity with mouse, rat, bovine, Stimulation of the CSF-1R upon binding to M-CSF activates MAPK, PI3K, and PLCγ signaling pathways (Chockalingam & Ghosh). Human and mouse M-CSF sequences are
Recombinant Human M-CSF, Animal-Free Protein - Bio-Techne
Recombinant Murine M-CSF. >95% by SDS-PAGE and HPLC analyses. Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine M-NFS cells is less than 2ng/ml, corresponding to a specific activity of >×10 5 IU/mg. Sterile Filtered White lyophilized (freeze-dried) powder Recombinant GM-CSF is a bioactive protein intended for use in cell culture applications. Recombinant human GM-CSF is intended for use in cell culture applications. GM-CSF is involved in many biological responses including the growth and development of granulocyte and macrophage progenitor cells, stimulation and the initiation of differentiation of Recombinant human M-CSF protein (Active) is a HEK Fragment protein 33 to aa range, >=95% purity Storage. Human GM-CSF Recombinant Protein is supplied as lyophilized material that is very stable at °C. It is recommended to reconstitute with sterile water at a concentration of mg/mL which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (% HSA or BSA) is recommended for long-term storage Overview. Macrophage colony-stimulating factor (M-CSF) is a homodimeric glycoprotein growth factor that regulates proliferation and differentiation of myeloid hematopoietic progenitor cells to mononuclear phagocytic cell lineages, including monocytes, macrophages, and osteoclasts. M-CSF is a crucial factor for the development of tissue In this study, we have obtained recombinant human GM-CSF fused to human ApoA-I. The choice of ApoA-I was not accidental, since this protein performs