F13A1 (Coagulation Factor XIII A Chain) is a Protein Coding gene. Diseases associated with F13A1 include Factor Xiii, A Subunit, Deficiency Of and Congenital Factor Xiii [HOST] its related pathways are Response to elevated platelet cytosolic Ca2+ and Diseases of [HOST] Ontology ; doi/physrev—Factor XIII (FXIII) is unique among clot-ting factors for a number of reasons: 1) it is a protransglutaminase, which becomes activated Blood coagulation factor XIII and factor XIII deficiency. Nov;30 (6) doi: /[HOST] Factor XIII (FXIII) is a multifunctional pro-γ-transglutaminase that, in addition to its well-known role in hemostasis, has a crucial role in angiogenesis, maintenance of pregnancy, wound healing, bone
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Expression of human coagulation factor XIII was depressed fold by the inclusion of base pairs of 3′ noncoding cDNA sequence before the yeast TPI1 terminator (Bishop et Factor XIII or fibrin stabilizing factor is a zymogen found in blood of humans and some other animals. It is activated by thrombin to factor XIIIa. Factor XIIIa is an enzyme of the Coagulation factor XIII is a zymogene that at the end of coagulation cascade cross-linked unstableand loose strand of fibrin to make stable clot. It circulates in Partial thromboplastin time (PTT) is the time it takes for a patient's blood to form a clot as measured in seconds. It is used to measure the activity of the intrinsic pathway of the clotting cascade. PTT tests the function of all clotting factors except factor VII (tissue factor) and factor XIII (fibrin stabilizing factor). Coagulation factor XIII (FXIII) is a protein that promotes fibrin stabilization by forming multiple covalent cross-links between fibrin monomers. Beside congenital FXIII deficiency, due to FXIII gene mutations, severe acquired FXIII deficiency has been described in association with autoantibodies against coagulation FXIII. Factor XIII, an enzyme that cross-links fibrin, belongs to the blood coagulation system. [ 1, 2] Screening for factor XIII, also known as fibrin-stabilizing Factor XIII, also known by the name fibrin stabilizing factor, is a key clotting factor in the coagulation cascade known for stabilizing the formation of a blood clot. The plasma form of Factor XIII is a protein heterodimer of A and B subunits expressed by bone marrow and mesenchymal lineage cells remarkable
Overview of the coagulation system - PMC - National Center for ...
Transglutaminase factor XIII (FXIII) is essential for hemostasis, wound healing, and pregnancy maintenance. Plasma FXIII is composed of A and B subunit dimers synthesized in cells of hematopoietic origin and hepatocytes, respectively Factor XIII (FXIII) is unique among clotting factors for a number of reasons: 1) it is a protransglutaminase, which becomes activated in the last stage of coagulation; 2) it works on an insoluble substrate; 3) its potentially active subunit is also present in the cytoplasm of platelets, monocytes, monocyte-derived macrophages, dendritic The biologic process of bone healing is complicated, involving a variety of cells, cytokines, and growth factors. As a result of bone damage, the activation of a clotting cascade leads to hematoma with a high osteogenic potential in the initial stages of healing. A major factor involved in this course of events is clotting Function. Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alphaplasmin inhibitor, or fibronectin, to the alpha chains of fibrin Introduction. Coagulation factor XIII is a protransglutaminase that has a major role in the final stage of blood coagulation [].The zymogen plasma FXIII (pFXIII) circulates in plasma as a tetramer (FXIII-A 2 B 2) consisting of two catalytic A subunits (FXIII-A) and two carrier/protective B subunits (FXIII-B).FXIII-A is The activity of blood coagulation factor XIII (FXIIIa) plays an important role in rodents as a healing factor after MI, whereas its role in healing and remodelling processes in humans remains unclear. We prospectively evaluated the relevance of FXIIIa after acute MI as a potential early prognostic marker for