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Full article: The naked mole-rat as an animal model in biomedical ...
Naked mole-rats (NMRs, Heterocephalus glaber) are the longest-lived rodents with a maximum life span exceeding 37 [HOST] exhibit a delayed aging phenotype and resistance to age-related functional decline/diseases. Specifically, they do not display increased mortality with age, maintain several physiological functions until NMR cell extracts were 2–3-fold more efficient at removing the bulky lesions, –3-fold more efficient at removing uracil, and about fold more efficient at cleaving the AP-site than the mouse cells, while DNA polymerase activities being as a whole higher in the mouse demonstrate different patterns of product distribution
Intestinal barrier function in the naked mole-rat: an ... - bioRxiv
The plot thickens. Their new paper reveals the answer, in the form of a sugar secreted by the mole rat’s cells called hyaluronan. The researchers’ interest in Missing: portable bench The naked mole-rat (Heterocephalus glaber) has many unusual biological features, including impaired colonic neuron sensitivity to acid and bradykinin, and resistance to chemically induced intestinal damage. However, insight into their intestinal barrier physiology is scarce. Here, we observed notable differences in intestinal tissue structure